Outcomes of patients with melioidosis treated with meropenem.

Treated with Meropenem Outcomes of Patients with Melioidosis

Cost-effectiveness analysis of parenteral antimicrobials for acute melioidosis in Thailand

BACKGROUND Melioidosis is a common community-acquired infectious disease in northeast Thailand associated with overall mortality of approximately 40% in hospitalized patients, and over 70% in severe cases. Ceftazidime is recommended for parenteral treatment in patients with suspected melioidosis. Meropenem is increasingly used but evidence to support this is lacking. METHODS A decision tree w...

99mTc-MDP whole body bone scan in a case of acute disseminated melioidosis

Melioidosis is a potentially fatal infectious disease occurring predominantly in the tropics, caused by a Gram-negative, motile, rod shaped obligatory aerobic non-spore forming bacillus, Burkholderia pseudomallei. It can produce localised or disseminated disease largely affecting immunocompromised patients. It is a challenge to identify melioidosis early as this disease can manipulate host’s ce...

Successful treatment of life-threatening melioidosis with activated protein C and meropenem.

Melioidosis is an endemic disease in southeast Asia and northern Australia, caused by Burkholderia pseudomallei. A typhoon-related outbreak occurred in southern Taiwan in July 2005. High mortality in melioidosis associated with bacteremic pneumonia and septic shock. We report a patient with life-threatening melioidosis who developed rapid progression of bacteremic pneumonia with acute respirato...

Whole-Genome Sequences of Burkholderia pseudomallei Isolates Exhibiting Decreased Meropenem Susceptibility

We report here paired isogenic Burkholderia pseudomallei genomes obtained from three patients receiving intravenous meropenem for melioidosis treatment, with post-meropenem isolates developing decreased susceptibility. Two genomes were finished, and four were drafted to improved high-quality standard. These genomes will be used to identify meropenem resistance mechanisms in B. pseudomallei.